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Psoriasis Following Administration of Antimalarial Drugs

M. Barry Kirschenbaum
JAMA. 1963;185(13):1044. doi:10.1001/jama.1963.03060130062022.
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THE ADMINISTRATION of antimalarial drugs to patients with psoriasis may cause a marked exacerbation of the psoriasis, leading to exfoliative dermatitis. Drs. Ziprkowski, Haim, and Bank1 first reported this observation in 1954 after administering 100 mg of quinacrine ( Atabrine) hydrochloride three times a day to nine patients with disseminated lesions of psoriasis. No additional topical or systemic treatment was used. Exfoliative dermatitis secondary to psoriasis developed in six of the nine patients. The psoriatic process exacerbated after 12 to 27 days of continuous daily treatment. The average latent period of only 21 days between institution of treatment and exacerbation of the psoriasis was much shorter than the 3 to 6 month period previously noted with quinacrine hydrochloride induced exfoliative dermatitis. The Year-book of Dermatology2 refers in a footnote to two similar cases of Drs. Sultzberger and Witten, in which exfoliative dermatitis resulted when patients with psoriasis were treated


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