A kidney from a cadaver was transplanted into a chronically uremic patient. Subsequently both of the patient's own diseased kidneys were removed. The renal homograft is sustaining life after 15 months. Although kidney function is subnormal and the patient has nitrogen retention and anemia, he feels well and is working regularly. Several episodes of threatened "rejection" of the transplant have been reversed with immunosuppressive therapy, and the kidney function has been stable for the last 5 months.