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Physiology of the circulation in human limbs in health and disease

Edward A. Edwards, MD
JAMA. 1963;185(4):334-335. doi:10.1001/jama.1963.03060040118051.
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This is a fairly extensive monograph of a limited but important segment of hemodynamics—that is, the anatomic and physiologic basis for the response of the vessels in the various tissues of the limb in the direction of vasodilatation or vasoconstriction. The book reflects the timing and locale of the author's researches—namely, Great Britain, in the time when instruments such as the plethysmograph and various calorimetric devices furnished the essential part of the data. The experiments reflect the painstaking, simple approach with these apparatus, from which some rather refined deductions are drawn. Readers of the book will immediately think of the experiments reported by Lewis and by Pickering.

While this book thus summarizes a large body of work done on the blood supply of the limbs, it fails to record work done upon the circulation as a whole and work done with more refined instrumentation, such as direct blood vessel flow


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