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USE AND MISUSE OF ANTIBIOTICS

JAMA. 1963;185(4):315. doi:10.1001/jama.1963.03060040099032.
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ABSTRACT

Effective chemotherapy for combating infectious diseases has become a possibility only during the past 15 years, and the list of complex, highly potent drugs is continually changing and increasing. The dramatic consequences of this break-through in pharmacological, microbiological, and clinical science are reflected in sharply declining death rates the world over. Unfortunately, however, the plethora of new drugs and combinations of drugs may be a mixed blessing to physicians who attempt to thread their way through a maze of conflicting claims concerning such complex matters as sensitivity spectra, blood levels, potency, and safety.

Many of the new antimicrobials are clearly outstanding contributions to the art of chemotherapy and are, as such, real triumphs of pharmacological research. Others are molecular modifications of established compounds and are introduced with claims that some desired feature—such as greater potency, more rapid absorption, more sustained blood levels, reduced bacterial resistance, or fewer side effects—has been

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The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
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