Evaluation of the Ephedrine Test

William Hamelberg, MD; Peter P. Bosomworth, MD
JAMA. 1963;184(11):904. doi:10.1001/jama.1963.03700240096029.
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To the Editor:  —At the AMA meeting in June, 1961, Dr. Crandell mentioned the "ephedrine response test" as a method of screening for surgery patients who had been receiving reserpine. He did not present confirming clinical data, nor has he done so subsequently to the best of our knowledge.Such a test, if indeed it were accurate in predicting hypotension in reserpinized patients, would appear to be a useful clinical tool. We were interested in investigating the proposed test. We tried to utilize the test under clinical circumstances for patients receiving reserpine and also other compounds known to produce a hypotensive effect in the anesthetized patient. While the size of the series does not permit statistically valid conclusions that the test is useful, it did indicate that it was not reliable in predicting hypotension in the anesthetized patients previously treated with reserpine. Any additional data collected to test Dr. Crandell's


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