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ARTICLE |

Statistical methods in clinical and preventive medicine.

James E. Grizzle, PhD
JAMA. 1963;184(5):431-432. doi:10.1001/jama.1963.03700180157025.
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ABSTRACT

This book is a collection of studies in which Professor Hill is the author or a co-author. They have been arranged into three sections: "Clinical Trial of Treatment," "The Field Trial of Vaccines," and "The Epidemiological Approach." Each section begins with papers presenting the authors' view of the use of statistics as an aid in seeking answers to questions that arise in clinical and preventive medicine. Following the introductory papers in each section are several others which illustrate the use of statistics in particular investigations.

Many of the papers are now regarded as classics by both medical investigators and statisticians. The papers include the trials of streptomycin versus bed-rest in the treatment of tuberculosis, cortisone versus aspirin in the treatment of rheumatoid arthritis, trials of B.C.G. and Vole Bacillus vaccines in the prevention of tuberculosis, and the famous studies of Doll and Hill on the relationship of smoking and carcinoma

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