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Glucagon: chemistry and function in health and disease.

Thomas F. Frawley, MD
JAMA. 1963;184(3):252-253. doi:10.1001/jama.1963.03700160128032.
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The concept of glucagon as a distinct hormone secreted by the pancreas and carried by the blood to one or more target organs is no longer controversial. It was more than 30 years ago that the existence of a hyperglycemic factor in insulin was first proposed. During the period which has since elapsed, innumerable research scientists, biochemists, and clinical investigators have devoted inestimable time and resources to elucidating the complexities of glucagon action and defining its characteristics. In a most thorough and painstaking fashion, the authors of this monograph have assembled all the worthwhile published data on glucagon, predigested it, and palatably served it in a concise, yet complete, attractive, and interesting fashion. As pioneers in the field of glucagon research, and as authors of numerous publications, they bring an authoritative viewpoint based on personal experience and an obviously wide acquaintance with the subject. This undoubtedly explains their ability to


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