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Resection of Carotid Body for Asthma

Julius H. Comroe Jr., MD
JAMA. 1963;184(2):161-162. doi:10.1001/jama.1963.03700150115029.
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To the Editor:  —For many years I have been actively engaged in the study of regulation of respiration (especially the reflex regulation of breathing by the chemoreceptors of the carotid and aortic bodies) and in the evaluation of pulmonary function in man (especially in patients with cardiopulmonary disease, including asthma). For these reasons, I was particularly interested in the article by Richard Overholt entitled "Resection of Carotid Body (Cervical Glomectomy) for Asthma," that appeared in the June 9, 1962, issue of The Journal (vol 180, p 809). Although the older work dealing with the effects of stimulation of the carotid body on airway resistance (Daly, M. De B., and Schweitzer, A.: J Physiol113:442, 1951) suggested that a decrease in partial pressure of oxygen dilates the airways, there is some justification for carotid body denervation in the more recent work of Widdicombe and Nadel (J Physiol [London]163:13,


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