Prefrontal saline lobotomy was performed for intractable pain in 20 patients. Satisfactory results were obtained in 15, with a follow up in some approaching one year (average three months). One patient died of intracerebral bleeding and two patients remained stuporous until death. Among survivors, there were only transient changes in personality and no serious psychiatric complications. Prefrontal saline lobotomy is preferred to other methods of lobotomy because it does not require special equipment and is relatively safe and effective.