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Bone Marrow Reactions

William R. Best, MD
JAMA. 1967;199(4):284. doi:10.1001/jama.1967.03120040094036.
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The author, professor of anatomy at the University of Bristol, has been engaged for many years in the quantitative study of hematopoiesis, generally employing as a model the healthy 400-gm male guinea pig. His ultimate goal is to describe hematopoiesis through a number of suitable equations. This monograph reviews his progress to date. He evolved a basic quantitative technique for estimating in an animal the total number of marrow cells of various types. Marrow reactions to certain stresses have been investigated. During the first 48 hours after hypoxia, there is an accelerated release of reticulocytes, followed by erythroid hyperplasia. Typhoid vaccine was administered intravenously to study neutrophilic reactions. There is normally a large granulocytic reserve which can be rapidly replenished. The neutrophil has a short life in the circulation. Chapters are devoted to eosinophil, basophil, and lymphocyte under various stresses.

While the volume indicates awareness of work done by others,


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