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Cytomegalic Inclusion Disease Following Multiple Blood Transfusions

Donald Henson, MD
JAMA. 1967;199(4):278-280. doi:10.1001/jama.1967.03120040088023.
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IN ADULTS generalized cytomegalic inclusion disease, disseminated cytomegalovirus infection, is rare, and when it occurs, is often associated with malignant disorders of the hematopoietic and reticuloendothelial systems, immunosuppressive therapy, or debilitating diseases.1-3 Clinically, generalized cytomegalic inclusion disease has not been completely defined in adults. Morphologically, it is manifested by the appearance within the lungs, liver, and other viscera of greatly enlarged cells containing intranuclear and less frequently cytoplasmic inclusions.

The following is a case of generalized cytomegalic inclusion disease in a debilitated adult who died after receiving multiple blood transfusions for trauma. Diagnosis was made microscopically by recognition of characteristic nuclear and cytoplasmic inclusions in tissues obtained by autopsy. The case is presented to emphasize the fact that in adults with morphologic evidence of cytomegalic inclusion disease, there is frequently a history of having received multiple blood transfusions.3-5

Report of a Case  A 44-year-old Negro man was admitted


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