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Candida tropicalis Meningitis in Hodgkin's Disease

Eliezer Henig, PhD; Meir Djaldetti, MD; Jack Pinkhas, MD; Andre De Vries, MD
JAMA. 1967;199(3):214-215. doi:10.1001/jama.1967.03120030118027.
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CANDIDA ALBICANS is the most frequent etiologic agent of candidiasis. Infection with this fungus is common in patients with predisposing diseases such as leukemia and lymphoma, or in patients being treated by steroids, antileukemic, and antibiotic drugs.1-4 The presently described case of Hodgkin's disease is unusual in that it was complicated by meningitis due to C tropicalis, which is generally considered as nonpathogenic.

Report of Case  A 43-year-old male clerk was admitted to the hospital in January 1964 because of fever, pruritus and weakness. His temperature was 101.5 F (38.6 C) and enlarged, nontender lymph glands were palpated in the right submandibular and axillary regions. A submandibular lymph gland biopsy revealed findings typical of Hodgkin's granuloma. Treatment with steroids and x-ray irradiation over the enlarged lymph glands led to marked improvement enabling the patient to return to his work.In January 1965, the patient suffered from increasing weakness, his

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