0
ARTICLE |

Anticoagulants in Myocardial Infarction

JAMA. 1966;198(12):1314. doi:10.1001/jama.1966.03110250128044.
Text Size: A A A
Published online

ABSTRACT

To the Editor:—  The report on long-term anticoagulant use in acute myocardial infarction (198: Nov 7, 1966, adv p 37) again emphasizes the confusion that exists in this field. One of the principal reasons for difficulty is that the therapeutic range for the depression of prothrombin activity has never been established. Usually, the maintenance dose is based on the empirical rule of keeping the one-stage prothrombin time at about twice normal. While this rule is a fairly trustworthy guide for avoiding untoward effects such as bleeding, it offers no assurance that an effective therapeutic depression of coagulability exists.The fear of hemorrhage in patients receiving anticoagulants is well justified. Bleeding may occur when the prothrombin time is in the desired range. This does not imply that the prothrombin time is unreliable but suggests that another factor has been superimposed. One of these factors is a sudden drastic change in the

Topics

Sign In to Access Full Content

Don't have Access?

Register and get free email Table of Contents alerts, saved searches, PowerPoint downloads, CME quizzes, and more

Subscribe for full-text access to content from 1998 forward and a host of useful features

Activate your current subscription (AMA members and current subscribers)

Purchase Online Access to this article for 24 hours

Figures

Tables

References

CME
Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.
NOTE:
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).

Multimedia

Some tools below are only available to our subscribers or users with an online account.

Sign In to Access Full Content

Related Content

Customize your page view by dragging & repositioning the boxes below.

Jobs
brightcove.createExperiences();