Ossification in Metastases From Carcinoma of the Breast

Suresh Patel, MD; Calixto J. Maso, MD
JAMA. 1966;198(12):1309-1311. doi:10.1001/jama.1966.03110250123038.
Text Size: A A A
Published online

EXTRASKELETAL ossification has been frequently reported in soft tissues, especially after trauma and chronic inflammation. Rarely bone formation occurs in the primary sites of extraskeletal tumors. The organs most frequently undergoing such change are skin, breast, prostate, colon, and urinary bladder.1-5 In animals, especially female dogs, bone metaplasia in breast tumors occurs frequently.6 Heterotopic ossification in metastatic areas from carcinoma of rectum7,8 and urinary bladder9 has been previously reported. The purpose of this paper is to report a case of ossification in metastases from carcinoma of breast. To our knowledge, this is the first such case reported.

Report of a Case  A 61-year-old white woman was first seen at Columbus Hospital on Sept 27, 1956 for a painful mass of one year's duration in the left breast. On physical examination, a small tender tumor was felt in the inner lower quadrant of the left breast. The mass


Sign In to Access Full Content

Don't have Access?

Register and get free email Table of Contents alerts, saved searches, PowerPoint downloads, CME quizzes, and more

Subscribe for full-text access to content from 1998 forward and a host of useful features

Activate your current subscription (AMA members and current subscribers)

Purchase Online Access to this article for 24 hours




Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).


Some tools below are only available to our subscribers or users with an online account.

Sign In to Access Full Content

Related Content

Customize your page view by dragging & repositioning the boxes below.