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Percutaneous Needle Biopsy of the Lung in Evaluation of Pulmonary Disorders

Felice Manfredi, MD; Richard Krumholz, MD
JAMA. 1966;198(11):1198-1202. doi:10.1001/jama.1966.03110240106037.
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Percutaneous needle biopsy of the lung has been shown to be of value in the diagnosis of both diffuse and localized diseases which involve the lung.1-10 The use of this procedure, in which a cutting-type needle (eg, Vim-Silverman, Franklin-Silverman, Jack) is used, has now been reported in approximately 400 cases. The results have been striking. The complications in most instances have been minimal, and no deaths from the procedure have been recorded. Histologically interpretable lung tissue has been returned in approximately 90% of the biopsy attempts (Table). The percentage return of tissue has been found to be higher in solid localized peripheral lesions than those demonstrating diffuse pulmonary parenchymal involvement, but the difference has been small. Tissue which has proved to be diagnostically useful, either primarily or in a supporting manner, has been returned in 77% of biopsies (Table). These figures are similar and comparable to those published for


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