0
We're unable to sign you in at this time. Please try again in a few minutes.
Retry
We were able to sign you in, but your subscription(s) could not be found. Please try again in a few minutes.
Retry
There may be a problem with your account. Please contact the AMA Service Center to resolve this issue.
Contact the AMA Service Center:
Telephone: 1 (800) 262-2350 or 1 (312) 670-7827  *   Email: subscriptions@jamanetwork.com
Error Message ......
ARTICLE |

Detection of Phenylketonuria in Newborn Infants

Helen K. Berry, MA; Betty S. Sutherland, MD; Barbara Umbarger, MA
JAMA. 1966;198(10):1114-1115. doi:10.1001/jama.1966.03110230130031.
Text Size: A A A
Published online

The purpose of screening infants for the presence of phenylketonuria is to permit early treatment and thus reduce the risk of mental retardation associated with this disease. It has been assumed that the chief problem lay in detection of this rare disorder, and the difficulties and hazards of treatment have not been emphasized. Death as a result of overtreatment of phenylketonuria has occurred. Growth failure, anemia, and rachitic bone changes are also described in treated children, presumably the result of phenylalanine deficiency. Mild to moderate mental retardation has been reported in infants who were treated by severe restriction of phenylalanine intake in spite of early detection of the disease.

It should be recognized that the detection of phenylketonuria in an infant is but the first step in a long-term treatment program if mental retardation is to be prevented. The most critical period of treatment comes during the first six months

Topics

Sign in

Create a free personal account to sign up for alerts, share articles, and more.

Purchase Options

• Buy this article
• Subscribe to the journal

Figures

Tables

References

Letters

CME
Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.

Multimedia

Some tools below are only available to our subscribers or users with an online account.

Sign in

Create a free personal account to sign up for alerts, share articles, and more.

Purchase Options

• Buy this article
• Subscribe to the journal

Related Content

Customize your page view by dragging & repositioning the boxes below.

Jobs
brightcove.createExperiences();