JAMA. 1966;198(8):814. doi:10.1001/jama.1966.03110210064023.
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To George E. Palade, MD, for his extraordinary series of original and fundamental contributions to the electron microscopy of biological materials. In the early 1950's, 25 years after research had started in electron optics, and 15 years after electron microscopes were available for research, Dr. Palade and his colleagues began mapping the detailed structure of various types of cells and developing the procedures which make it possible to correlate at the molecular level the structure of these cells, with their biochemical activity.

In the past 15 years, as the ability to visualize small objects increased from the best light microscopes to the 400 times more powerful electron microscope, Dr. Palade's work has pioneered the study of the nature of cellular processes at a molecular level.

Dr. Palade developed the technique of fixing cells, an essential step in preparing them for electron microscopy. He first described and named the fine structure


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