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Viruses Inducing Cancer: Implications for Therapy

R. M. Mulligan, MD
JAMA. 1966;198(3):331. doi:10.1001/jama.1966.03110160159064.
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This symposium on tumor viruses, with 30 papers and 80 participants, is divided into two main parts. Part 1, covering viral infection and tumors, takes up murine leukemia, avian leukosis and related neoplasms, mammary tumors, induction of tumors and transformation of cells by deoxyribonucleic acid viruses, molecular structure of adenovirus, and virus-specific complement-fixing neoantigens in virus-free but virus-induced tumor cells.

Part 2 concerns the diagnosis and management of viral infections, including virus detection, cell-bound and humoral cytotoxic antibodies in tumor immunity, prophylaxis, and therapy. Some of the topics dealt with are immunologic relationships among some of the murine leukemia viruses, virus-host interactions of avian tumors, immunology of spontaneous mammary carcinoma in mice, immunization against tumors induced by human adenovirus, comparative molecular structure of oncogenic and nononcogenic adenoviruses, and detection of oncogenic viral infections by the fluorescent antibody technique. Of special interest are the papers on electron microscopic structure of Newcastle


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