0
September 26, 1966, Vol 197, No. 13 >
ARTICLE | September 26, 1966

Absence of Tolbutamide Effect on Anticoagulant Therapy

Russell L. Poucher, MD; Thomas J. Vecchio, MD
JAMA. 1966;197(13):1069-1070. doi:10.1001/jama.1966.03110130069019.
Text Size: A A A
Published online
Article
References

Data on 224 diabetic patients were collected to determine the effect of tolbutamide (Orinase) on coumarin anticoagulant therapy and prothrombin times, using insulin injection-treated diabetic patients as controls. This retrospective survey indicates that there is no potentiating or inhibitory effect of tolbutamide, as compared to insulin, on anticoagulant therapy. When tolbutamidetreated patients were compared, there was no statistically (or clinically) significant difference at the 0.05 level or beyond, with respect to average initial dosage or maintenance dosage of anticoagulant, and day 4 and average prothrombin time. Likewise, there was no significant difference between treatment groups in the number of patients who were "adequately" maintained on anticoagulants. In conclusion, this study fails to demonstrate a difference in effect between tolbutamide and insulin on anticoagulant therapy, either potentiating or inhibitory.

Sign In to Access Full Content

Don't have Access?

Register and get free email Table of Contents alerts, saved searches, PowerPoint downloads, CME quizzes, and more

Subscribe for full-text access to content from 1998 forward and a host of useful features

Activate your current subscription (AMA members and current subscribers)

Purchase Online Access to this article for 24 hours

Figures

Tables

Interactive Graphics

Video

Country-Specific Mortality and Growth Failure in Infancy and Yound Children and Association With Material Stature

Use interactive graphics and maps to view and sort country-specific infant and early dhildhood mortality and growth failure data and their association with maternal

References

Letters

Submit a Letter
CME
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
Clear Answers | Save For Later
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.
NOTE:
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s “Cited By” API will populate this tab (http://www.crossref.org/citedby.html).
Compression-Only CPR: Pushing the Science Forward
Cone
AAM 2010;304:1493-1495.
All you need to read in the other general journals
BMJ 2010;341:c5893-c1494.
Submit a Response

Some tools below are only available to our subscribers or users with an online account.

Sign In to Access Full Content

Related Content

Customize your page view by dragging & repositioning the boxes below.

Jobs

More Listings at
JAMACareerCenter.com >

© 2013 American Medical Association. All Rights Reserved.
Powered bySilverchair Information Systems