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Article |

Histiocytosis X: Response to Vinblastine Sulfate

Jerome S. Siegel, MC; Charles A. Coltman, MC
JAMA. 1966;197(6):403-406. doi:10.1001/jama.1966.03110060077019.
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The designation histiocytosis X was coined as a unifying diagnostic term by Lichtenstein to draw attention to the pathological unity made up of several diverse and transitional syndromes, ie, eosinophilic xanthomatous granuloma, Hand-Schüller-Christian syndrome and Letterer-Siwe disease. Lichtenstein preferred the terms localized, chronic disseminated, and acute disseminated histiocytosis X to represent these related entities. A 40-year-old white man presented with localized histiocytosis X which progressed to a chronic disseminated form of the disease that could not be distinguished from Hand-Schüller-Christian disease. Almost complete resolution of this very resistant tumor occurred following treatment with vinblastine sulfate.


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