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Primary Hepatoma

Robert J. Stein, MD
JAMA. 1966;197(5):377-378. doi:10.1001/jama.1966.03110050115044.
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Always welcome, for any specialized subject, is a brief treatise which presents numerous provocative concepts, both clinical and experimental. This volume fulfills all of these criteria. The geographic distribution of primary hepatoma and its relationship to cirrhosis and kwashiorkor is well described. The idea that environmental factors may play a greater role than intrinsic ones in the etiology of primary hepatoma is well supported by proving the carcinogenicity of cycasin in cycad nuts, senecio alkaloids, and Aspergillus flavus.

The inclusion of electron-microscopic morphology of experimental animal and human primary hepatomas, and the study of these tumors in the trout, emphasizes the importance of comparative pathology in the study of disease. The biochemical mechanisms of primary hepatic cancer are well summarized by the individual investigators and the facts presented in a clear and lucid manner.

Perhaps the highlight of this small volume is the discussion section. Experts in the field give


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