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'A Disturbing Cephalic Phenomenon'

JAMA. 1966;197(5):34. doi:10.1001/jama.1966.03110050020007.
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ABSTRACT

Migraine Still Deprives Many Of Productivity  Migraine—the intense, nauseous headache which not only deprives millions of persons of productivity and pleasure but also keeps them apprehensive—still is as much a mystery in some respects as it was centuries ago.In Britain, where it's estimated that more than two million persons have this problem, a Migraine Trust recently was formed to seek funds for comprehensive research in this area over the next decade.An Italian investigator, Federigo Sicuteri, MD, professor and director of the Headache Center, University of Florence Department of Medicine, told the American Association for the Study of Headache, meeting in Chicago, that:"We have been developing the hypothesis that the so-called peripheral vascular pain is not produced by strange or unknown substances, but by the very same principles that regulate microcirculation."Referring to "vasoneuroactive substances," a grouping he conceded may be arbitrary on pharmacologic gounds but is convenient

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