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Peutz-Jeghers Syndrome With Colonic Adenocarcinoma and Ovarian Tumor

Arthur L. Humphries Jr., MD; Mason H. Shepherd, MD; Hans J. Peters, MD
JAMA. 1966;197(4):296-298. doi:10.1001/jama.1966.03110040106027.
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PEUTZ-JEGHERS syndrome consists of intestinal polyps and intraoral melanin spots and is said to be hereditary. It was described in 1921 by Peutz,1 and more recently (1949) by Jeghers et al.2 It has since been recognized frequently, and at least 300 cases have been reported. The subject was reviewed in the medical literature several times.3-6

The following case is presented because of the unusual combination of the Peutz-Jeghers syndrome and an ovarian neoplasm. Furthermore, one polyp of the colon removed eight years ago was malignant. The patient is now well and symptom free.

Report of a Case  In 1958, this 41-year-old Negro woman entered the Eugene Talmadge Memorial Hospital of the Medical College of Georgia because of pain in the left costovertebral angle, dysuria, and urinary urgency. The results of urinalyses were normal except for a few white blood cells found in the urine. The residual urine


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