0
ARTICLE |

Diphenylhydantoin And Arrhythmia

Sattar Farzan, MD
JAMA. 1966;197(1):63. doi:10.1001/jama.1966.03110010115040.
Text Size: A A A
Published online

ABSTRACT

To the Editor:—  In a recent report by Fulop et al (196:454, 1966) there appears to be an obvious faulty interpretation of the electrocardiograms, resulting in erroneous conclusion on the effect of diphenylhydantoin in a patient receiving replacement thyroid therapy. The first tracing, which was interpreted by the authors as atrial flutter with block, reveals characteristics of atrial tachycardia which has a rate of only 182 beats per minute. Interestingly, intravenous injection of diphenylhydantoin has simply abolished the atrioventricular block without changing the atrial rate (remaining 182 beats per minute).Therefore, "supraventricular tachycardia" was not due to the effect of the drug. Moreover, almost instantaneous electrocardiographic changes upon intravenous injection of diphenylhydantoin which lasted only a short period of time makes the authors' explanation of the mechanism of action of the drug in their case irrelevant. It is more likely that diphenylhydantoin had a direct effect on the cardiac

Topics

Sign In to Access Full Content

Don't have Access?

Register and get free email Table of Contents alerts, saved searches, PowerPoint downloads, CME quizzes, and more

Subscribe for full-text access to content from 1998 forward and a host of useful features

Activate your current subscription (AMA members and current subscribers)

Purchase Online Access to this article for 24 hours

First Page Preview

View Large
/>
First page PDF preview

Figures

Tables

References

CME
Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.
NOTE:
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).

Multimedia

Some tools below are only available to our subscribers or users with an online account.

Sign In to Access Full Content

Related Content

Customize your page view by dragging & repositioning the boxes below.

Jobs
brightcove.createExperiences();