0
We're unable to sign you in at this time. Please try again in a few minutes.
Retry
We were able to sign you in, but your subscription(s) could not be found. Please try again in a few minutes.
Retry
There may be a problem with your account. Please contact the AMA Service Center to resolve this issue.
Contact the AMA Service Center:
Telephone: 1 (800) 262-2350 or 1 (312) 670-7827  *   Email: subscriptions@jamanetwork.com
Error Message ......
ARTICLE |

Antibiotic-Related Respiratory Depression

Alfred F. Parisi, MD
JAMA. 1966;196(13):1161. doi:10.1001/jama.1966.03100260099044.
Text Size: A A A
Published online

ABSTRACT

To the Editor:—  I have read with interest a number of Clinical Notes in The Journal in the past 18 months on antibiotic-related respiratory depression (190:421, 1964; 194:298, 1965; 196:181, 1966). Particularly disturbing is the consistency of the theme of reports of apnea induced by the closely related polypeptide antibiotics polymyxin B sulfate and sodium colistimethate.In each of these reports the patients were receiving large or maximally recommended doses of these agents; there was indication of neurologic dysfunction (dysphagia, circumoral paresthesias, blurred vision) hours to days prior to sustained apnea. In spite of symptoms of neurotoxicity, drug administration was continued in unchanged dosages. Two of the patients were azotemic at the inception of therapy (which is in itself an indication for lowered dosage), and the third became azotemic during treatment. In one case, serum concentration of the drug at the time of the apneic episode was

Topics

Sign in

Create a free personal account to sign up for alerts, share articles, and more.

Purchase Options

• Buy this article
• Subscribe to the journal

First Page Preview

View Large
First page PDF preview

First Page Preview

View Large
First page PDF preview

Figures

Tables

References

CME
Also Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
Your answers have been saved for later.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.

Multimedia

Some tools below are only available to our subscribers or users with an online account.

Sign in

Create a free personal account to sign up for alerts, share articles, and more.

Purchase Options

• Buy this article
• Subscribe to the journal

Related Content

Customize your page view by dragging & repositioning the boxes below.

Jobs
brightcove.createExperiences();