JAMA. 1966;196(13):1151-1152. doi:10.1001/jama.1966.03100260089029.
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The possibility of a relationship between the gut and the skin has been implied in clinical reports for many years, dating back to the earliest descriptions of tropical sprue in the 18th century. An article in the June Archives of Dermatology describes the incidence and nature of the involvement of the small intestine in several skin diseases.1 Although the subjects were selected at random from patients whose dermatitis was severe enough to warrant inpatient management, none had symptoms or past illness referrable to the gastrointestinal tract. Using biopsies of the small intestine, the investigators observed a total of 32 patients, of whom 16 had eczematous dermatitis and three had psoriasis. Ten patients with inherited ichthyotic conditions were selected, because of the known clinical association between malabsorption syndromes and acquired ichthyosis. Three children with acrodermatitis enteropathica were studied because the nature of the lesion of the gut in this disease


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