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ARTICLE |

TO EMULATE... SERENDIP WITHOUT PRACTICING SERENDIPITY

JAMA. 1966;196(10):908. doi:10.1001/jama.1966.03100230152038.
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ABSTRACT

Somehow within the framework of our own particular folklore, the three Princes of Serendip are presented as practitioners of fortuitous misdirection. They have become the fellows who set out to look for a new refrigerant and wound up making a fortune from a new rocket propellant after one of them blew up his house, a consequence of lighting a candle when he neglected to pay for the electricity.

But this is only folklore. In the true tale they were masters of keen observation as well as of deductive reasoning (a horse passed this way at full gallop— presumably carrying a double burden; the depth, angle and periodicity of the hoofprints, and the dried spittle on the wayside foliage told us).

Thus has it ever been with those who first discover the adverse reaction to a therapeutic agent. The keen observation of the aberrant pattern—the canted, deepened hoofprint or the recrudescent

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The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
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