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ARTICLE |

The Effects of Limitation of Activity Upon the Human Body

Frederic J. Kottke, MD
JAMA. 1966;196(10):825-830. doi:10.1001/jama.1966.03100230069017.
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The functional capacity of any organ is dependent within physiological limits upon the intensity and frequency of its activity. Although rest may be protective for a damaged organ it results in progressive loss of functional capacity for normal organs. Limitation of activity during prolonged bed rest causes significant deterioration of multiple organ systems including the skeletal, neuromuscular, cardiovascular, respiratory, urogenital, and nervous systems. Total inactivity of muscle results in loss of strength of approximately 3% per day. Neuromuscular and emotional control and intellectual performance are all impaired by prolonged bed rest. Cardiovascular function decreases during bed rest more rapidly than it is restored when activity is resumed. Years may be required to restore the calcium lost from the skeleton during immobilization.

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The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
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