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Interference Halts 'Ping Pong' Staph

JAMA. 1966;196(8):33. doi:10.1001/jama.1966.03100210019007.
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Atechnique used to halt nursery epidemics has been extended by its originators to interrupt "ping pong" staphylococcal disease in families.

A preliminary study of "bacterial interference" with 14 families indicates the method—which substitutes an avirulent bacterium for the recurrent strain on the nasal mucosa—can be used with outpatients, according to Marvin Boris, MD.

Families in the recent New York City study all had at least a oneyear history of recurrent infection in two or more members. Lesions involved were primarily dermal, but also included four intra-rectal abscess and single instances of osteomyelitis, peritonitis, and septicemia. The same strain of Staphylococcus was isolated from all family members with the same lesion.

Each participant was first given a 10-20 day course of penicillins systemically and antibacterial agents to carrier sites such as the nose.

After two consecutive cultures proved negative for the recurrent bacteria, the major part of the study began.



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