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Aneurysmal Degeneration of Femoropopliteal Arterial Homografts

Hendrick B. Barner, MD; James A. DeWeese, MD; W. Andrew Dale, MD; Earle B. Mahoney, MD
JAMA. 1966;196(7):631-634. doi:10.1001/jama.1966.03100200071022.
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The evanescent era of the arterial homograft began nearly 12 years ago and ended five years later in most centers. It is of interest to obtain a long-term evaluation of this method of arterial reconstruction not only to place it in its proper perspective but also because arterial homografts are once again being used. Organ homotransplantation entails homotransplantation of moderate and smaller-sized arteries which may be vulnerable to the same degenerative changes as the isolated arterial homograft. Thirty-five femoropopliteal arterial homografts have been reviewed, with the observation that all of the patent grafts have become aneurysmal. This finding has led us to believe that all similar-sized homografts that remain patent will eventually become aneurysmal.

Clinical Material  Arterial homografts were obtained from patients under 45 years of age who died following trauma or nonmalignant and noninfectious diseases. The grafts were removed under sterile conditions, placed in physiologic saline containing 500,000 units


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