Experimental Coxsackievirus Endocarditis

George E. Burch, MD; Nicholas P. DePasquale, MD; S. C. Sun, MD; Alfred R. Hale, MD; William J. Mogabgab, MD
JAMA. 1966;196(4):349-352. doi:10.1001/jama.1966.03100170091030.
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Although occasional references to viral endocarditis have appeared in the literature,1,2 neither cardiologists nor pathologists generally consider endocarditis or valvulitis to be a complication of viral infection. However, it has been suggested that subendocardial fibroelastosis may be viral in etiology and it has recently been observed that children with subendocardial fibroelastosis have significant skin reactivity to mumps antigen.3 In a previous report from this laboratory, it was postulated that some instances of acute and chronic valvulitis in man may be viral in This opinion was based on the following considerations: (1) a relatively large number of patients considered to have rheumatic valvular disease give no history of rheumatic fever, (2) chronic valvular disease may occur without Aschoff bodies or other pathological stigmata of rheumatic valvulitis, (3) acute valvulitis has been reported in experimental animals following viral infection,5-7 and (4) there is no basis for assuming that the


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