Gluten Enteropathy and Skeletal Disease

John R. Ross, MD; S. Peter Gibb, MD; Donald E. Hoffman, MD; Eugene P. Clerkin, MD; Willard E. Dotter, MD; Lewis M. Hurxthal, MD
JAMA. 1966;196(3):270-274. doi:10.1001/jama.1966.03100160120035.
Text Size: A A A
Published online

This exhibit illustrates our experience with the problem of a primary absorption defect commonly recognized as gluten enteropathy, and it focuses attention principally on one of its least emphasized manifestations which relates directly to skeletal abnormalities.

Scope  Gluten enteropathy, an entity variously termed nontropical sprue, celiac disease of adults and children, and idiopathic steatorrhea, is primary malabsorption usually associated with inflammation and villous atrophy of the small-bowel mucosa. Although gluten enteropathy is frequently observed in childhood, the symptoms of the disease may appear for the first time in adult life.The mucosal changes appear to result from local toxicity caused by gliadin, the water-soluble fraction obtained from the alcohol extraction of gluten, a protein found primarily in wheat, barley, oats, and rye. The mechanism of this mucosal toxicity has not been established, but current knowledge suggests that an inborn error of metabolism exists which is manifested as a deficiency of


Sign In to Access Full Content

Don't have Access?

Register and get free email Table of Contents alerts, saved searches, PowerPoint downloads, CME quizzes, and more

Subscribe for full-text access to content from 1998 forward and a host of useful features

Activate your current subscription (AMA members and current subscribers)

Purchase Online Access to this article for 24 hours

First Page Preview

View Large
First page PDF preview




Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).


Some tools below are only available to our subscribers or users with an online account.

Sign In to Access Full Content

Related Content

Customize your page view by dragging & repositioning the boxes below.