Two patients in whom renal function was virtually absent have been maintained on long-term intermittent hemodialysis for 20 months. Technical problems during dialysis were infrequent and the silicone rubber-Teflon arteriovenous shunts performed well. Major medical problems included a need for frequent blood transfusion with accompanying febrile reactions in one patient, uremic peripheral neuropathy, and intermittent bouts of noninflammatory musculoskeletal pain and stiffness. Hypertension was controlled by adequate ultrafiltration and hyperuricemia was well controlled by allopurinol, a drug which proved to be removed effectively by hemodialysis. Control of hyperkalemia between dialyses was facilitated by the presence of an increased fecal excretion of potassium. The performance of military corpsmen who were trained in all aspects of dialysis was highly satisfactory.