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Preoperative Radiotherapy in Cancer

James J. Nickson, MD; Arvin S. Glicksman, MD
JAMA. 1966;195(11):922-926. doi:10.1001/jama.1966.03100110090024.
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Despite major technological improvements, the goal, the "cure" or control of most cancers, has not been achieved. Some primary neoplasms have a good probability of cure following surgical extirpation and others after irradiation. Approximately 300,000 cancers will be diagnosed this year in the United States. Of these, no more than one third will arise in regions of the body where treatment for cure is a realistic hope, defining this as 40% survival for five years. In the past, definitive therapy has involved either surgery or radiation. Relatively little attempt has been made to combine them deliberately for cure. Planned combinations of radiotherapy and surgery need reevaluation, since they may offer significant improvement of survival. By this is meant a planned combined procedure which requires that a predetermined dose of radiation is followed after a stated interval by a definitive surgical procedure. The reports in the literature have been organized for

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