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Prophylactic Value of Dapsone in Leprosy

Dharmendra, MD
JAMA. 1966;195(9):787. doi:10.1001/jama.1966.03100090121035.
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To the Editor:—  For the past few years at the Chingleput Central Leprosy Teaching and Research Institute, we have been engaged in investigating the prophylactic value of treatment of healthy child contacts of "open" cases of leprosy with dapsone (diaminodiphenylsulfone). An interim report has just been published (Leprosy in India37 [Oct] 1965).This present analysis covers the results in 585 individuals of whom 291 belong to the prophylaxis group and 294 to a control group receiving placebo tablets in a doubleblind study. A period of 2 1/4 years is covered. The patients represent about 85% of the known contacts in a population of more than 2 million.The early results suggest that under the conditions of the investigation dapsone has a definite protective value against the disease.


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