0
ARTICLE |

Protein Abnormalities in Neuromuscular Diseases—Part 1

W. King Engel, MD; Dale E. McFarlin, MD; Genevieve A. Drews, MD; R. Dean Wochner, MD
JAMA. 1966;195(9):754-760. doi:10.1001/jama.1966.03100090088019.
Text Size: A A A
Published online

Dr. W. King Engel (Moderator):  We will begin the discussion of protein abnormalities in various neuromuscular diseases by first explaining our use of the term "neuromuscular diseases." Figure 1 is a diagram of what is called the "motor unit." The anterior-horn motor neuron (or lower motor neuron) lies in the anterior horn of the spinal cord, and the peripheral extension of that neuron goes out through the anterior root, through the peripheral nerve, to the terminal branches of that nerve cell. At the end of the terminal branches are the neuromuscular junctions, the connections between the nerve cell and the numerous muscle fibers, generally several hundred, that one neuron innervates. A motor neuron and the muscle fibers innervated by it comprise a "motor unit." Diseases that affect any part of the motor unit—that is, the anterior horn cell, peripheral nerve, neuromuscular junction, or muscle—are termed "neuromuscular diseases." In various conditions,

Topics

Sign In to Access Full Content

Don't have Access?

Register and get free email Table of Contents alerts, saved searches, PowerPoint downloads, CME quizzes, and more

Subscribe for full-text access to content from 1998 forward and a host of useful features

Activate your current subscription (AMA members and current subscribers)

Purchase Online Access to this article for 24 hours

First Page Preview

View Large
/>
First page PDF preview

Figures

Tables

References

CME
Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.
NOTE:
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).

Multimedia

Some tools below are only available to our subscribers or users with an online account.

Sign In to Access Full Content

Related Content

Customize your page view by dragging & repositioning the boxes below.

Jobs
brightcove.createExperiences();