We're unable to sign you in at this time. Please try again in a few minutes.
We were able to sign you in, but your subscription(s) could not be found. Please try again in a few minutes.
There may be a problem with your account. Please contact the AMA Service Center to resolve this issue.
Contact the AMA Service Center:
Telephone: 1 (800) 262-2350 or 1 (312) 670-7827  *   Email: subscriptions@jamanetwork.com
Error Message ......
Article |

Flu Hybrids: A Cause of Vaccine Obsolescence?

JAMA. 1966;195(8):50. doi:10.1001/jama.1966.03100080022007.
Text Size: A A A
Published online


Influenza, the most variable of known viruses, can produce antigenically unique hybrids by union of two or more unrelated serotypes, a Cornell University investigator has found.

The results of such combinations, like the children of genetically contrasting mates, differ from their parents significantly, said Edwin D. Kilbourne, MD.

Laboratory proof that such matings occur helps explain the sudden influenza mutations that periodically have made existing vaccines obsolete, he told the Fifth Gustav Stern Symposium in New York City.

London scientists, he added, recently have proved that human and avian influenza viruses may combine in vitro. This would be an additional mechanism for extreme mutations.

Improved Techniques  Improved virological mating and detection techniques now have reached the point where the influence of both parents can be seen in a viral hybrid. Previously, it had been thought that viral unions resulted in a substance immunologically related to only one parent.Antigenic hybrids,


Sign in

Purchase Options

• Buy this article
• Subscribe to the journal
• Rent this article ?

First Page Preview

View Large
First page PDF preview




Also Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
Please click the checkbox indicating that you have read the full article in order to submit your answers.
Your answers have been saved for later.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.


Some tools below are only available to our subscribers or users with an online account.

0 Citations

Sign in

Purchase Options

• Buy this article
• Subscribe to the journal
• Rent this article ?

Related Content

Customize your page view by dragging & repositioning the boxes below.