Syndromes of Q Fever

Jerachmiel Eshchar, MD; Mordechai Waron, MD; Walter J. Alkan, MD
JAMA. 1966;195(5):390-393. doi:10.1001/jama.1966.03100050098034.
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SINCE THE original description of Q fever, it has been established that Coxiella burnetii has a worldwide distribution. The abundance of reports on epidemic and sporadic cases of Q fever, displaying a protean and often uncharacteristic symptomatology, encouraged us to undertake a systematic study of this disease entity and its part in the causation of various clinical syndromes, such as infectious hepatitis,1 fever of uncertain origin, and infectious mononucleosis.

It is the purpose of this communication to present seven cases of Q fever, five of which were originally labelled "fever of uncertain origin," and two of which displayed a clinical picture suggesting infectious mononucleosis.

Materials and Methods  A group of 119 patients classified as having "fever of uncertain origin" and a group of 13 with the clinical diagnosis of infectious mononucleosis were studied for Q fever.The microscopic-slide agglutination test, introduced by Babudieri2 was employed in all cases


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