Drug-Induced Diseases

Edmund L. Dubois, MD
JAMA. 1965;194(12):1333. doi:10.1001/jama.1965.03090250067035.
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This compilation of 20 papers presented at a second symposium on drug-induced diseases held in Leyden, the Netherlands, in October 1964, has a great deal of variation in the value of the published presentations. Louis Lasagna gives a good summary of the problem and points out that 5% to 7% of hospitalized patients suffer from adverse drug reactions. Two chapters present material in sufficient detail to be of specific value. The first is a review by Dr. H. M. Peck et al of the Merck Institute for Therapeutic Research, "The Evaluation of Drugs for Their Effects on Reproduction and Fetal Development." They discuss the techniques and problems involved in carrying over to humans the results of animal experiments in this field. Peck and associates emphasize that the "final demonstration of safety relative to toxicity for the human, including the reproduction cycle and the fetus, will rest upon human experience until


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