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December 20, 1965, Vol 194, No. 12 >
ARTICLE | December 20, 1965

Failure of Penicillin to Alter Acute Rheumatic Valvulitis

Vaisman B. Samuel, MD; Guasch L. Julio, MD; Vignau I. Alberto, MD; Correa T. Enrique, MD; Schuster C. Augusto, MD; Edward A. Mortimer; Charles H. Rammelkamp, MD
JAMA. 1965;194(12):1284-1286. doi:10.1001/jama.1965.03090250018003.
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A controlled study of the effects of penicillin on 165 patients with acute rheumatic fever has failed to demonstrate any alteration, attributable to the antibiotic, in valvular sequelae. The results suggest that the Streptococcus in the bacterial form does not play a continuing role in an acute episode of rheumatic fever once rheumatic symptoms have appeared.

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