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December 6, 1965, Vol 194, No. 10 >
ARTICLE | December 6, 1965

Studies of a Method of Inducing Specific Lymphopenia in Dogs

James S. Wolf, MD; David M. Hume, MD
JAMA. 1965;194(10):1119-1121. doi:10.1001/jama.1965.03090230087022.
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The lymphocyte plays a significant role in the development of transplant immunity. Many methods have been used to produce a lymphopenia in animals in order to study the effect of lymphocyte depletion on the homograft response. These methods include total and subtotal body radiation and use of antimetabolites, corticosteroids, antilymphocyte sera, and thoracic-duct fistulae. These methods all produce detrimental general alterations in the host, in addition to the desired lymphopenia. Cronkite1 and his group have produced temporary lymphocyte depletion in calves by extracorporeal radiation of circulating blood. Thomas et al2 have shown a similar response to extracorporeal blood radiation in leukemic humans. The marked radiosensitivity of lymphocytes in vitro has been demonstrated in studies by Schrek and Stefani.3 β-emitting isotopes have been inserted into arterial prostheses4 and into the right atrium of the heart5 in attempts to produce experimental lymphocyte depletion. In this study, an intraarterial

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BMJ 2010;341:c5893-c1494.
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