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Periodic Myelodysplasia and Periodic Pancreatitis

Hobart A. Reimann, MD
JAMA. 1965;194(9):1024. doi:10.1001/jama.1965.03090220080037.
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To the Editor:—  The reply to the query (193:752, 1965) about a possible relationship between cyclic neutropenia and recurrent pancreatitis needs amendation and amplification. If the episodes of neutropenia recur at three-week intervals as in most other instances, the condition is better termed "periodic myelodysplasia." Examples of periodic pancreatitis recurrent at similar intervals were described in the Journal of the Indian Medical Profession (9:4189, 1962) and in Periodic Diseases, (Philadelphia: F. A. Davis Co., 1963). Hence, there is reason to believe that there is a relationship. Evidence indicates that overlapping of features, their concurrence, or transition occurs among various periodic disorders. Furthermore, Gilsdorf et al report a central nervous system influence on experimentally produced pancreatitis (abstracted, JAMA188:447, 1964). Theoretically, hypothalamic excitation provokes periodic disorders (Ann NY Acad Sci117:589, 1964).


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