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Chromosome Studies in Familial Bowel Disease

W. H. Jacobs, MD; G. Eisemann, MD
JAMA. 1965;194(9):1022. doi:10.1001/jama.1965.03090220078030.
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To the Editor:—  Occasionally, patients with ulcerative colitis, regional enteritis, or ileocolitis are observed who give a family history of inflammatory bowel disease. During the past year, we have studied six individuals, representing four families with inflammatory bowel disease.Method: Chromosome studies were done by use of venous blood, according to the method of Moorhead et al, (Exp Cell Res 20:613, 1960) with modifications. The chromosome number in all patients studied was 46, and the idiograms were normal. The accompanying Table describes the patients.Comment: In a recent review dealing with familial ulcerative colitis, ileitis, and ileocolitis, Kirsner and Spencer (Ann Intern Med59:133-144, 1963) reported that 91 of 1,339 patients gave evidence of similar disease in relatives. It was rare for this disease to occur in more than two members of one family. Morris (Gut 6:176, 1965) recently described a family in which eight members had


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