Since the time of Virchow it has been postulated that a change in the chemistry of the endothelium lining blood vessels is one of the primary events in the initiation of thrombosis. It is well-known that negatively charged surfaces, such as glass, are clot-promoting in vitro as a direct result of their ability to activate Hageman factor (Factor XII). The problem has been, whether Hageman factor must be activated in vivo for thrombosis to occur and, if so, what kind of a biochemical and biophysical process takes place at the endothelial surface to initiate the coagulation.
There have been two methods of approach to this problem. The first is that of the coagulationist who examines the result of treating coagulation proteins with various surfaces in vitro. The second is that of the investigator who measures the biophysical counterparts of normal blood flow and thrombus formation. This monograph is the written