Biophysical Mechanisms in Vascular Homeostasis and Intravascular Thrombosis

Robert T. Breckenridge, MD
JAMA. 1965;194(7):834-835. doi:10.1001/jama.1965.03090200142043.
Text Size: A A A
Published online


Since the time of Virchow it has been postulated that a change in the chemistry of the endothelium lining blood vessels is one of the primary events in the initiation of thrombosis. It is well-known that negatively charged surfaces, such as glass, are clot-promoting in vitro as a direct result of their ability to activate Hageman factor (Factor XII). The problem has been, whether Hageman factor must be activated in vivo for thrombosis to occur and, if so, what kind of a biochemical and biophysical process takes place at the endothelial surface to initiate the coagulation.

There have been two methods of approach to this problem. The first is that of the coagulationist who examines the result of treating coagulation proteins with various surfaces in vitro. The second is that of the investigator who measures the biophysical counterparts of normal blood flow and thrombus formation. This monograph is the written


Sign In to Access Full Content

Don't have Access?

Register and get free email Table of Contents alerts, saved searches, PowerPoint downloads, CME quizzes, and more

Subscribe for full-text access to content from 1998 forward and a host of useful features

Activate your current subscription (AMA members and current subscribers)

Purchase Online Access to this article for 24 hours

First Page Preview

View Large
First page PDF preview




Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).


Some tools below are only available to our subscribers or users with an online account.

Sign In to Access Full Content

Related Content

Customize your page view by dragging & repositioning the boxes below.