We're unable to sign you in at this time. Please try again in a few minutes.
We were able to sign you in, but your subscription(s) could not be found. Please try again in a few minutes.
There may be a problem with your account. Please contact the AMA Service Center to resolve this issue.
Contact the AMA Service Center:
Telephone: 1 (800) 262-2350 or 1 (312) 670-7827  *   Email: subscriptions@jamanetwork.com
Error Message ......
Article |

Hemodynamic Factors in Atherosclerosis-Reply

Meyer Texon, MD; Samuel Butler
JAMA. 1965;193(11):980. doi:10.1001/jama.1965.03090110117048.
Text Size: A A A
Published online


Thickening of the intima is due to proliferation of its components as a response to diminished lateral pressure or the suction effect of the flowing blood. The point is not that atherosclerotic changes (atheroma) occur where the intima is already normally thickened but that the first sign of developing atherosclerosis is a slight reactive thickening of the intima. A vessel may be considered to have a normally thickened intima only in the sense that no pathological or clinical findings are attributable to the diminution of volumetric flow due to encroachment on the lumen by the thickened intima. The thickening signals the start of the disease and the continued operation of local hydraulic factors produces progressive pathological changes which evolve into the atherosclerotic plaque. All the stages in this pathological process have been produced hemodynamically in our laboratory.

Hydrodynamics of flow are not "obviously the same" in the rich, the poor,


Sign in

Purchase Options

• Buy this article
• Subscribe to the journal
• Rent this article ?

First Page Preview

View Large
First page PDF preview




Also Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
Please click the checkbox indicating that you have read the full article in order to submit your answers.
Your answers have been saved for later.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.


Some tools below are only available to our subscribers or users with an online account.

0 Citations

Sign in

Purchase Options

• Buy this article
• Subscribe to the journal
• Rent this article ?

Related Content

Customize your page view by dragging & repositioning the boxes below.