Effect of Testosterone Enanthate and Alkylating Agents on Multiple Myeloma

Isadore Brodsky, MD; Lewis H. Dennis, MD; Norman A. DeCastro, MD; Luther Brady, MD; S. Benham Kahn, MD
JAMA. 1965;193(11):874-878. doi:10.1001/jama.1965.03090110012003.
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Testosterone enanthate was used in conjunction with uracil mustard or melphalan in the treatment of seven cases of multiple myeloma. With the administration of testosterone enanthate leukopenia was not as severe after a second identical course of chemotherapy. Two additional cases were treated with testosterone enanthate alone, and subjective improvement and a rise in hemoglobin concentration occurred. This study suggests that testosterone enanthate may be a useful adjunct in the treatment of multiple myeloma with alkylating agents.


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