Access to paid content on this site is currently suspended due to excessive activity being detected from your IP address Please contact the publisher to request reinstatement.
We're unable to sign you in at this time. Please try again in a few minutes.
We were able to sign you in, but your subscription(s) could not be found. Please try again in a few minutes.
There may be a problem with your account. Please contact the AMA Service Center to resolve this issue.
Contact the AMA Service Center:
Telephone: 1 (800) 262-2350 or 1 (312) 670-7827  *   Email: subscriptions@jamanetwork.com
Error Message ......
Article |

Precipitate from Cold-thawed Plasma Potent in Therapy for Hemophiliacs

JAMA. 1965;193(8):27-30. doi:10.1001/jama.1965.03090080067038.
Text Size: A A A
Published online


Use of a precipitate from coldthawed plasma—until recently thought to be valueless—may solve several major problems inherent in conventional therapy for hemophiliacs.

Judith G. Pool, PhD, Stanford University Medical Center, is the investigator who first found—almost by accident—that the threadlike substance precipitated during standard cold-thawing of plasma contains concentrated antihemophilic globulin (AHG).

Recently, Dr. Pool reported a simple technique for extracting this protein fraction. Since then, clinicians at Stanford Medical Center have used the precipitate in solution to infuse 14 patients more than 60 times. There were no apparent side effects.

Dr. Pool, a physiologist, described to The Journal these advantages of the concentrate:

  • In vivo assay indicates the crycoprecipitate is 30 times as potent in AHG activity per given weight of protein as fresh frozen plasma, the conventional therapy, and 20 times that of normal fresh plasma.

  • Since the precipitate can be dissolved in small amounts of


Sign in

Purchase Options

• Buy this article
• Subscribe to the journal
• Rent this article ?

First Page Preview

View Large
First page PDF preview




Also Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
Please click the checkbox indicating that you have read the full article in order to submit your answers.
Your answers have been saved for later.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.


Some tools below are only available to our subscribers or users with an online account.

0 Citations

Sign in

Purchase Options

• Buy this article
• Subscribe to the journal
• Rent this article ?

Related Content

Customize your page view by dragging & repositioning the boxes below.