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Pneumocystis carinii Pneumonia in a Family

James M. Watanabe, MD; Harry Chinchinian, MD; Claude Weitz, MD; Samuel K. McIlvanie, MD
JAMA. 1965;193(8):685-686. doi:10.1001/jama.1965.03090080047017.
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PLASMA-CELL PNEUMONIA due to infection with Pneumocystis carinii is commonly seen in Europe but has been comparatively rare in North America. Recently, an increasingly large number of cases have been reported in the United States and Canada. Many cases have been quite sporadic; however, there are a few areas in which large numbers of cases have been seen—namely, North Carolina1 and Montreal.2 The disease has occurred mainly in premature or debilitated infants. It has been reported in epidemic form in nurseries for the premature; however, isolated cases are the rule. In a few instances, the disease has occurred in siblings but these instances were associated with hypogammaglobulinemia3 or other serious diseases. Most adult cases4 were associated with chronic or fatal diseases, such as cancers, cytomegalic-inclusion disease, collagen diseases. No coexisting disease could be found in two cases.5,6

Report of Cases  The following concerns a family


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