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Serum Sickness and Recurrent Angioedema After Bee Sting

Richard K. Sheehan, MD
JAMA. 1965;193(2):155-156. doi:10.1001/jama.1965.03090020069022.
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LITERATURE on insect sensitivity reactions makes ample mention of hives, angioedema (single episodes), and anaphylactoid and even fatal episodes as consequences of insect stings. Recently, a rather atypical reaction was noted following a bee sting. Because of the bizarre nature of the clinical sequences, it was thought deserving of report.

Report of a Case  A 5-year-old boy was stung by a bee in the left temporal area on Sept 15, 1963. Because of the marked local reaction in the sting area, the child was given emergency treatment with diphenhydramine (Benadryl) hydrochloride, 50 mg intravenously, and triamcinolone (Kenacort), 4 mg orally four times daily, by the family physician. Over the first four days there was gradual improvement. However on the fifth day following the incident marked swelling had again recurred in the sting area, with progression to the left temporofacial area. In spite of repeated medication the child had seven such


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