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Propositions in Hormonal Treatment of Advanced Cancers

Charles B. Huggins, MD
JAMA. 1965;192(13):1141-1145. doi:10.1001/jama.1965.03080260029008.
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A problem in science can be solved in only one way: a question is proposed in such a simple way that Nature must provide a categorical answer. But man cannot devour a big meal with a single gulp. For difficult problems a series of connected interrogations are necessary; as a result of the answers the most difficult problem progressively becomes simpler as solutions emerge. The cure of cancer has proved to be unusually difficult to obtain. But progress has been made as I shall show.

New areas of investigation can be introduced only through a conceptual scheme, but the investigator discovers the truth by activity. Science is ruled by the duumvirate of idea and technique. In medicine the idea frequently comes from observation of the vivid but essentially simple displays of Nature at the bedside and in the laboratory; both theaters are of high importance in the quest for cures


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